Melanin Concentrating Hormone Signaling Deficits in Schizophrenia:...
AbstractBackgroundEvidence from anatomical, pharmacological, and genetic studies supports a role for the neuropeptide melanin concentrating hormone (MCH) system in modulating emotional and cognitive...
View ArticleStaging of Schizophrenia with the use of PANSS: An international multi-center...
AbstractIntroductionA specific clinically relevant staging model for schizophrenia has not yet been developed. The aim of the current study was to evaluate the factor structure of the PANSS and to...
View ArticleBehavioral pharmacology of novel kappa opioid receptor antagonists in rats
AbstractBackgroundNew treatments for stress-related disorders including depression, anxiety and Substance Use Disorder are greatly needed. Kappa opioid receptors (KORs) are expressed in central nervous...
View ArticleBalanced activation of striatal output pathways by faster off-rate PDE10A...
AbstractBackgroundFaster off-rate competitive enzyme inhibitors are generally more sensitive than slower off-rate ones to binding inhibition by enzyme substrates. We previously reported that cAMP...
View ArticleLearning experience reverses catecholaminergic effects on adaptive behavior
AbstractBackgroundCatecholamines are important for cognitive control and the ability to adapt behavior, e.g. after response errors. A prominent drug that modulates the catecholaminergic system is...
View ArticleHuman Plasma BDNF is associated with Amygdala-Prefrontal Cortex Functional...
AbstractBackgroundPreclinical studies suggest that decreased levels of brain-derived neurotrophic factor (BDNF) in the amygdala play a role in anxiety and alcohol use disorder (AUD). The association...
View ArticleChanges in white matter microstructure after electroconvulsive therapy for...
AbstractBackgroundTreatment-resistant depression (TRD) is among the most debilitating conditions in psychiatry. Recent studies have associated alterations in white matter microstructure measured with...
View ArticleReduced consolation behaviors in physically stressed mandarin voles:...
AbstractBackgroundConsolation is a type of empathy-like behavior that has recently been observed in some socially living rodents. Despite the growing body of literature suggesting that stress affects...
View ArticleThe role of bacteria and its derived metabolites in chronic pain and...
AbstractBackgroundChronic pain is frequently comorbid with depression in clinical practice. Recently, alterations in gut microbiota and metabolites derived therefrom have been found to potentially...
View ArticleAnalysis of time-course, dose-effect, and influencing factors of...
AbstractObjectiveModel-based meta-analysis was used to describe the time-course and dose-effect relationships of antidepressants and also simultaneously investigate the impact of various factors on...
View ArticleCandidate biomarkers of suicide crisis syndrome: what to test next? A concept...
AbstractBackgroundThere has been increasing interest in both suicide-specific diagnoses within the psychiatric nomenclature and related biomarkers. Because the Suicide Crisis Syndrome (SCS)--an...
View ArticleInhibitory Control of Basolateral Amygdalar Transmission to the Prefrontal...
AbstractBackgroundBasolateral amygdalar (BLA) projections to the prefrontal cortex (PFC) play a key role in modulating behavioral responses to stress stimuli. Among the different neuromodulators known...
View ArticleThe CINP guidelines on the definition and the evidence-based interventions...
AbstractIntroductionResistant Bipolar disorder (BD) is a major mental health problem related to significant disability and overall cost. The aim of the current study was to perform a systematic review...
View ArticleNaturally Derived Polyphenols Protect Against Corticosterone-Induced Changes...
AbstractBackgroundPolyphenols are phytochemicals that have been associated with therapeutic effects in stress-related disorders. Indeed, studies suggest that polyphenols exert significant...
View ArticleAssociation between side effects and blood microRNA expression levels and...
AbstractIntroductionAntidepressant drugs are effective therapies for Major Depressive Disorder (MDD); however, they are frequently associated with side effects. Although there is some evidence for a...
View ArticleRegulation of CRF mRNA in the rat extended amygdala following chronic...
AbstractBackgroundCocaine withdrawal activates stress systems. Females are more vulnerable to relapse to cocaine use and more sensitive to withdrawal-induced negative affect. Delta opioid receptors...
View ArticleAntipsychotic Polypharmacy: A Dirty Little Secret or a Fashion?
AbstractThe term polypharmacy was originally coined to refer to problems related to multiple drug consumption and excessive drug use during the treatment of a disease or disorder. In the treatment of...
View ArticleNeurofunctional differences related to methamphetamine and sexual cues in men...
AbstractBackgroundStimulant use and sexual behaviors have been linked in behavioral and epidemiological studies. Although methamphetamine-related neurofunctional differences have been investigated, few...
View ArticleTranscranial random noise stimulation for the acute treatment of depression:...
AbstractBackgroundTranscranial electrical stimulation has broad potential as a treatment for depression. Transcranial random noise stimulation (tRNS), which delivers randomly fluctuating current...
View ArticlePolygenetic Risk Scores for Major Psychiatric Disorders Among Schizophrenia...
AbstractBackgroundThe genetic etiology of schizophrenia (SCZ) overlaps with that of other major psychiatric disorders in samples of European ancestry. The present study investigated transethnic...
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